Bio

Kexiang Xu, Head of Biorepository

Kexiang joined CAG in March, 2011. She has been responsible for a range of functions in our wet lab, including PBMC isolation, EBV transformation, cell culture, and bisulfite methylation. She was also heavily involved in establishing the BGI@CHOP next-generation sequencing (NGS) lab, transforming it from an empty space to a fully-functional facility, implementing a range of worksheet and protocols for libraries preparation and process. She has worked as the Manager of the NGS Lab with preparation through Caliper Sciclone. At present, Kexiang works at our Illumina Genotyping lab.

She holds a Bachelor’s Degree of Science with a major in Biology from the University of Zhejiang in China, and has 5 years laboratory manager experience. In total, Kexiang has17 years of research experience, including 3 years as NGS manager, 2 years as lab manager in Tissue Microfabrication, 6 years’ drosophila neuroscience experience, 3.5 years in Plant Molecular Genetics and 2.5 years in Microbiology Pharmaceuticals.

Publications

Defining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogaster.
Jung J, van Jaarsveld MT, Shieh SY, Xu K, Bonini NM.
Genetics. 2011 Jan;187(1):61-71. doi: 10.1534/genetics.110.121418. Epub 2010 Nov 1.



Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3.
Jung J, Xu K, Lessing D, Bonini NM.
Hum Mol Genet. 2009 Dec 15;18(24):4843-52. doi: 10.1093/hmg/ddp456. Epub 2009 Sep 25.



A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1.
Watson MR, Lagow RD, Xu K, Zhang B, Bonini NM.
J Biol Chem. 2008 Sep 5;283(36):24972-81. doi: 10.1074/jbc.M804817200. Epub 2008 Jul 2.



Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila.
Li LB, Xu K, Bonini NM.
J Biol Chem. 2007 Dec 28;282(52):37694-701. Epub 2007 Oct 23.



Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging.
Meulener MC, Xu K, Thomson L, Ischiropoulos H, Bonini NM.
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12517-22. Epub 2006 Aug 7. Erratum in: Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14978. Thompson, Leonor [corrected to Thomson, Leonor].



Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.
Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, Labaer J, Rochet JC, Bonini NM, Lindquist S.
Science. 2006 Jul 21;313(5785):324-8. Epub 2006 Jun 22.



An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Müller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wüllner U, Frank R, Hartl UF, Bonini NM, Wanker EE.
EMBO J. 2006 Apr 5;25(7):1547-58. Epub 2006 Mar 9.



An ATP-binding cassette transporter GhWBC1 from elongating cotton fibers.
Zhu YQ, Xu KX, Luo B, Wang JW, Chen XY.
Plant Physiol. 2003 Oct;133(2):580-8. Epub 2003 Aug 21.



Impaired polar auxin transport in cotton li mutant.
Zhu YQ, Xu K, Chen XY.
Journal of Plant Physiology and Molecular Biology. 2003 29(1): 15-20.



Isolation of genes preferentially expressed in cotton fibers by cDNA filter arrays and RT-PCR.
Li CH, Zhu YQ, Meng YL, Wang JW, Xu K, Zhang T, Chen X.
Plant Science. 2002 O163: 1113-1120.



Meeting Abstracts

An ABC transporter from cotton fibers.
Zhu Y, Luo B, Xu K, Chen X. 2003, Plant and animal genomes XI conference, San Diego, CA, USA, January 11-15, 2003 Isolation of genes preferentially expressed in cotton fiber cells.
Zhu Y, Wang J, Li C, Xu K, Lin Z, Chen, X. 4th china-singapore bioscience workshop, shanghai, China, May 14-17, 2001 A comprehensive comparison of commercially available hybridization and amplification based exome enrichment methods.
Guettouche T, Xu K, Dong L, Tian T, Kim C, Hakonarson H. The American Society of Human Genetics, Oct 18-22, 2014

Patent

Chen Xiao-Ya, Zhu Yong-Qing, Xu Ke-Xiang, Zhou Bao-Liang, Chen song, Lin Zhi-Ping, Transgenic cotton fibers expressing the fibroin gene and the related genetic engineering method. Accession number:02111145.6, Date of application: March 22, 2002.