Marina joined CAG in June 2010 as a Senior Research Scientist because of her interest and desire to work in field of type 1 diabetes. At present, she is carrying out a functional study of CLEC16A – a novel autoimmunity-associated gene - using cell culture and mouse models. She is also interested in the rare molecular disease program and is fascinated with the possibilities opened to scientists with next-generation sequencing. She is trying to become a productive member of the team that is working to solve the mysteries of rare disorders.
Marina is a molecular biologist by training, an expert in broad molecular and cell culture techniques. As a postdoctoral fellow at Children’s National Medical Center (Washington, DC) she was working on developing gene therapy strategies for Duchene muscular dystrophy and at the same time learned Affymetrix microarray technology and analysis. She was promoted to Assistant Professor of Pediatrics, and in this role carried out studies of downstream consequences of biochemical defects in muscular dystrophies and was working on developing microarray-based molecular diagnosis for problematic limb-girdle dystrophies. In addition, she worked with murine models of muscular dystrophies and successfully administered the projects (e.g. staffing, budget), collaborated with other researchers, and produced several peer-reviewed publications.
Marina holds a MS in biophysics from St. Petersburg Technical University, Russia and a PhD in biochemistry and molecular biology from the Institute of Experimental Medicine, St. Petersburg, Russia.
The diabetes susceptibility gene Clec16a regulates mitophagy.
Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA.
Cell. 2014; Jun 19;157(7):1577-90.
Genes Involved in Type 1 Diabetes.
Bakay M, Pandey R and Hakonarson H.
Genes (Basel). 2013; Sep 16;4(3):499-521.
What have genome-wide association studies contributed to the understanding of the pathogenesis and future management of Type 1 diabetes?
Bakay M and Hakonarson H.
Diabetes Management. 2012; March; 2(2):77-80.
Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease, Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy.
Bakay M., Pandey R. and Hakonarson H.
InTech. 2011; ISBN: 978-953-307-362-0.
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
Bradfield J, Qu H, Wang K, Zhang H, Sleiman P, Kim C, Mentch F, Glessner J, Thomas K, Chiavacci R, Imielinski M, Monos D, Pandey R, Bakay M, Grant S, Polychronakos K, Hakonarson H.
PLoS Genet 7. 2011; e1002293.
Copy Number Variations in CTNNA3 and RBFOX1 Associate with Pediatric Food Allergy.
Li J, Fung I, Glessner JT, Pandey R, Wei Z, Bakay M, Mentch FD, Pellegrino R, Wang T, Kim C, Hou C, Wang F, Chiavacci RM, Thomas KA, Spergel JM, Hakonarson H, Sleiman PM.
Journal of Immunology. 2015; Jul 17.
Sources of variability and effect of experimental approach on expression profiling data interpretation.
Bakay M, Chen YW, Borup R, Zhao P, Nagaraju K, Hoffman EP.
BMC Bioinformatics. 2002; 2002;3:4. Epub 2002 Jan 31.