Xiao Chang, Postdoctoral Fellow

Xiao Chang completed his Ph.D. in Bioinformatics at the Chinese Academy of Sciences in 2010. Soon afterwards, he was funded by the ZNI Young Scholar Program to work as a Postdoctoral Fellow at the University of Southern California. Since 2013, he has been working as a Postdoctoral Fellow at CAG. Dr. Chang has a strong background in Computer Science and Molecular Biology. His research interests include Software Development, NGS Data Analysis, Population Genetics, Comparative Genomics, and Systems Biology. His research results has been published in various international scientific journals, including Cell Research, Human Molecular Genetics, the Journal of Medical Genetics, PloS Computational Biology and Bioinformatics. He developed the web server wANNOVAR, which has been widely used by researchers working with NGS data. He has also been invited as a reviewer to PloS One, BMC Cancer, BioMed Research International, and others.

His research interests include:

  • Developing bioinformatics pipelines and computational biology algorithms for next-generation sequencing data.
  • Developing network-based pathway analysis methods for post-GWAS analysis of psychiatric disorders
  • Applying integrative genomics methods (including GWAS analysis, CNV analysis, gene expression analysis) on cancers for gene discovery.

  • Publications

    CAG Publications*

    *(Please note that publications are updated intermittently and may not be completely up-to-date)

    Genome-wide association study of serum minerals levels in children of different ethnic background.
    Chang X, Li J, Guo Y, Wei Z, Mentch FD, Hou C, Zhao Y, Qiu H, Kim C, Sleiman PM, Hakonarson H.
    PLoS One. 2015;10(4):e0123499. doi: 10.1371/journal.pone.0123499.

    Rare variants at 16p11.2 are associated with common variable immunodeficiency.
    Maggadottir SM, Li J, Glessner JT, Li YR, Wei Z, Chang X, Mentch FD, Thomas KA, Kim CE, Zhao Y, Hou C, Wang F, Jørgensen SF, Perez EE, Sullivan KE, Orange JS, Karlsen TH, Chapel H, Cunningham-Rundles C, Hakonarson H.
    J Allergy Clin Immunol. 2015 Jun;135(6):1569-77. doi: 10.1016/j.jaci.2014.12.1939. Epub 2015 Feb 10.

    Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia.
    Banerjee A, Wang HY, Borgmann-Winter KE, MacDonald ML, Kaprielian H, Stucky A, Kvasic J, Egbujo C, Ray R, Talbot K, Hemby SE, Siegel SJ, Arnold SE, Sleiman P, Chang X, Hakonarson H, Gur RE, Hahn CG.
    Mol Psychiatry. 2014 Oct 21. doi: 10.1038/mp.2014.115. [Epub ahead of print]