CHOP Research Institute

Center for Applied Genomics

Today's Research Becomes Tomorrows Cure

A Children's Hospital of Philadelphia-led team of researchers has quantified the heritability of nine pediatric-onset autoimmune diseases. CHOP's Hakon Hakonarson and his team examined genotyping data from more than 5,000 unrelated pediatric autoimmune disease patients and 36,000 controls and found that type 1 diabetes and juvenile idiopathic arthritis had the highest levels of heritability, as they reported today in Nature Communications.
Article by: GenomeWeb; October 09, 2015

Researchers will analyze DNA sequencing in common pediatric conditions and evaluate how sharing this information with patients impacts treatment decisions.
Article by: Philly Voice; September 19, 2015

CHOP researchers conducted a meta-analysis of 10 childhood-onset autoimmune diseases — such as inflammatory bowel disease, type 1 diabetes, and juvenile idiopathic arthritis, among others — to uncover 22 loci that were shared among multiple pediatric autoimmune diseases, as they reported today in Nature Medicine.
Article by: GenomeWeb; August 24, 2015

CHOP Research’s Distinguished Research Trainee Awards provide institution-wide recognition for exceptional CHOP Research trainees. The 2015 Awards sees two young researchers from the Center for Applied Genomics each claim the prestigious award.
Article by: Cornerstone (CHOP); June 05, 2015

In the largest genetic study to date of a challenging immunodeficiency disorder, CAG scientists have identified a gene that may be a "missing link" between overactive and underactive immune activity. The gene candidate also plays a key role in autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and allergies.
Article by: Medical XPress; April 22, 2015

A new study from The Children’s Hospital of Philadelphia shows body mass index (BMI) during infancy may help to predict if a child will be obese by age four.
Article by: CHOP Cornerstone; March 24, 2015

Genomics researchers from the Center for Applied Genomics (CAG) at The Children’s Hospital of Philadelphia investigating a serious, rare disease called common variable immunodeficiency (CVID) have discovered a gene linked to immune defense.
Article by: CHOP Cornerstone; March 13, 2015

Scientists in Philadelphia have identified four new genes associated with the severe food allergy eosinophilic esophagitis (EoE). Because the genes appear to have roles in other allergic diseases and in inflammation, the findings may point toward potential new treatments for EoE.
Article by: Science Codex; November 21, 2014

Collaboration will bring together the premier pediatric genomics research organization, Center for Applied Genomics (CAG), with ex vivo gene therapy innovator, Medgenics.
Article by: GlobeNewswire; November 12, 2014

Scientists in Philadelphia have discovered a gene that dictates how much sleep we need, and say some of us are just programmed to need less sleep than others.
Article by: BBC; August 6, 2014