CHOP Research Institute

Center for Applied Genomics

Today's Research Becomes Tomorrows Cure

CAG in the Press

In the decade since the Human Genome Project produced the first map of DNA sequences in the human genome, scientists throughout the world have combed through genome data to identify genes and gene variants that cause human disease. A new study suggests that researchers may need to broaden their search farther afield to pinpoint rare but powerful disease-causing mutations.
Article by: Science Centric; January 26, 2011

Our NEJM paper on genetic variations associated with risk for childhood asthma is ranked as 23andMe's number 2 genetic story of 2010.
Article by: 23andMe; January 15, 2011

A defective gene appears to contribute to most cases of childhood asthma, a finding that could lead to a better understanding of allergies, U.S. researchers reported on Wednesday.
Article by: National Post; January 1, 2011

Using a process that could help unravel the causes of a variety of complex diseases, scientists probing the genetics of height have discovered dozens more uncommon variants, adding to the nearly 200 already known.
Article by: Medpage Today; December 30, 2010

Major depression patients have a duplicated region of DNA on chromosome 5, according to a new research. The gene involved plays an important role in the development of nerve cells, adding to evidence that disruptions in neurotransmission networks form a biological basis for depression.
Article by: Scify News; December 02, 2010

Scientists at The Children's Hospital of Philadelphia have identified a number of areas along the genome that could play a role in the genetic underpinnings of eating disorders.
Article by: MSNBC; November 22, 2010

Scientists at The Children's Hospital of Philadelphia have identified both common and rare gene variants associated with the eating disorder anorexia nervosa. In the largest genetic study of this psychiatric disorder, the researchers found intriguing clues to genes, including those active in neuronal signaling and in shaping interconnections among brain cells.
Article by: The Children's Hospital of Philadelphia; November 19, 2010

A new study by pediatric researchers has added to the evidence that genes have a strong influence on childhood obesity.
Article by: The Children's Hospital of Philadelphia; October 14, 2010

As the director of the Center for Applied Genomics at Children's Hospital of Philadelphia, Hakon Hakonarson has led a variety of genome-wide association studies to detect the genetic causes of childhood diseases such as attention-deficit hyperactivity disorder, asthma, autism, diabetes, epilepsy, inflammatory bowel disease, pediatric cancer, and schizophrenia.
Article by: GenomeWeb; October 12, 2010

To find genes associated with EoE, a team of researchers led by Dr. Marc Rothenberg at the Cincinnati Children’s Medical Center Hospital and Dr. Hakon Hakonarson at the Children’s Hospital of Philadelphia performed a genome-wide association analysis.
Article by: Quest for Cures; July 28, 2010