CHOP Research Institute

Center for Applied Genomics

Today's Research Becomes Tomorrows Cure

CAG in the Press

Scientists at The Children's Hospital of Philadelphia have identified both common and rare gene variants associated with the eating disorder anorexia nervosa. In the largest genetic study of this psychiatric disorder, the researchers found intriguing clues to genes, including those active in neuronal signaling and in shaping interconnections among brain cells.
Article by: The Children's Hospital of Philadelphia; November 19, 2010
 

A new study by pediatric researchers has added to the evidence that genes have a strong influence on childhood obesity.
Article by: The Children's Hospital of Philadelphia; October 14, 2010
 

As the director of the Center for Applied Genomics at Children's Hospital of Philadelphia, Hakon Hakonarson has led a variety of genome-wide association studies to detect the genetic causes of childhood diseases such as attention-deficit hyperactivity disorder, asthma, autism, diabetes, epilepsy, inflammatory bowel disease, pediatric cancer, and schizophrenia.
Article by: GenomeWeb; October 12, 2010
 

To find genes associated with EoE, a team of researchers led by Dr. Marc Rothenberg at the Cincinnati Children’s Medical Center Hospital and Dr. Hakon Hakonarson at the Children’s Hospital of Philadelphia performed a genome-wide association analysis.
Article by: Quest for Cures; July 28, 2010
 

Scientists have found dozens of new autism-related genes, according to a study that eventually could help doctors develop better ways to diagnose and treat the condition.
Article by: USA Today; June 10, 2010
 

In findings that may speed the search for disease-causing genes, a new study challenges the prevailing view that common diseases are usually caused by common gene variants (mutations). Instead, say genetics researchers, the culprits may be numerous rare variants, located in DNA sequences farther away from the original "hot spots" than scientists have been accustomed to look.
Article by: The Children's Hospital of Philadelphia; May 26, 2010
 

Genetics researchers analysed the genomes of patients with schizophrenia and found numerous copy number variations-deletions or duplications of DNA sequences-that increase the risk of developing the neurodegenerative disease.
Article by: The Times of India; May 23, 2010
 

Major variations in the number of genes carried in a person's genome have been linked with schizophrenia, in a study that provides further evidence of the important role played by genetics in raising the risk of the illness, which affects one in 100 people.
Article by: The Independent (UK); May 11, 2010
 

Pediatric researchers analyzing DNA variations in type 1 diabetes and inflammatory bowel disease have found a complex interplay of genes. Some genes have opposing effects, raising the risk of one disease while protecting against the other. In other cases, a gene variant may act in the same direction, raising the risk for both diseases.
Article by: The Children's Hospital of Philadelphia; March 22, 2010
 

Pediatrics researchers have identified the first major gene location responsible for a severe, often painful type of food allergy called eosinophilic esophagitis (EoE). In this disease, which may cause weight loss, vomiting, heartburn and swallowing difficulties, a patient may be unable to eat a wide variety of foods.
Article by: The Children's Hospital of Philadelphia; March 08, 2010