CHOP Research Institute

Center for Applied Genomics

Today's Research Becomes Tomorrows Cure

Hakon hakonarson

Hakon Hakonarson


Hakon Hakonarson, M.D., Ph.D., is Director of the Center for Applied Genomics and is also an associate professor of pediatrics at The University of Pennsylvania School of Medicine. He leads a $40 million commitment from CHOP to genotype approximately 100,000 children, an initiative that has gained nationwide attention in the Wall Street Journal, New York Times, Time Magazine, Nature and Science.

Patrick Sleiman

Patrick Sleiman

Associate Director

Patrick Sleiman is one of the lead analytical scientists at The Center for Applied Genomics. Patrick’s foundation in genetics lay in his doctorate from the University of London. During his fellowship in London, he was awarded a Bogue Fellowship to analyze copy number variants (CNV) in Parkinson’s patients at The Cold Spring Harbor Institute. His research interests at CAG lay in the genetic variants associated with neurodegenerative diseases and pediatric asthma.

Avni Santani

Avni Santani

Director of Clinical Laboratories, Strategic Partnerships and Innovation

Dr. Avni Santani, Ph.D, is Director of Clinical Laboratories, Strategic Partnerships and Innovation at CAG, where she oversees the clinical genomics program for rare pediatric disorders. She is also an Assistant Professor of Clinical Pathology at the University of Pennsylvania and Director in the Division of Genomic Diagnostics at CHOP. Dr. Santani received her Master’s in Medical Molecular Genetics at the University of Aberdeen and her PhD in Genetics at Texas A&M University. She holds specialty board certifications in Clinical Molecular Genetics and Clinical Cytogenetics.